Occurrence and relative risks of autoimmune/inflammatory diseases among first-degree relatives of patients with Wegener’s granulomatosis (WG) and among first-degree relatives of matched general population controls. Except for total numbers, data are hazard ratio and 95% CI.
| Disease (ICD10) | Total Number of Affected Relatives/Controls | Children | Siblings | Parents | All Biological First-degree Relatives | Spouses |
|---|---|---|---|---|---|---|
| Any autoimmune/inflammatory disease* | 345/2697 | 1.30 (1.12–1.51) | 1.32 (1.04–1.67) | 1.42 (1.07–1.89) | 1.32 (1.18–1.49) | 1.02 (0.67–1.55) |
| Hypothyroidism (E03) | 17/134 | 0.96 (0.44–2.09) | 0.99 (0.36–2.74) | 3.66 (1.43–9.37) | 1.31 (0.79–2.17) | 0.65 (0.09–4.94) |
| Hyperthyroidism (E05) | 19/180 | 1.16 (0.64–2.11) | 1.59 (0.67–3.76) | 0.30 (0.04–2.19) | 1.08 (0.68–1.73) | 1.04 (0.25–4.43) |
| Insulin-dependent diabetes (E10) | 57/512 | 1.14 (0.80–1.62) | 0.85 (0.45–1.60) | 1.76 (0.98–3.16) | 1.16 (0.89–1.52) | 1.91 (0.85–4.29) |
| Multiple sclerosis (G35) | 18/97 | 2.06 (1.16–3.65) | 1.11 (0.26–4.64) | 2.55 (0.55–11.82) | 1.92 (1.16–3.16) | 2.42 (0.52–11.21) |
| Crohn’s disease (K50) | 18/130 | 1.50 (0.82–2.75) | 1.01 (0.31–3.28) | 1.76 (0.51–6.09) | 1.42 (0.87–2.33) | 1.12 (0.15–8.64) |
| Ulcerative colitis (K51) | 32/287 | 1.12 (0.71–1.78) | 1.37 (0.61–3.04) | 0.94 (0.22–4.02) | 1.15 (0.79–1.70) | ** |
| Psoriatic arthritis (L40.5) | 72/531 | 1.24 (0.89–1.73) | 1.57 (1.01–2.44) | 1.82 (0.95–3.49) | 1.41 (1.10–1.81) | 1.34 (0.62–2.93) |
| All inflammatory polyarthritis combined | 74/514 | 1.66 (1.11–2.49) | 2.04 (1.15–3.62) | 0.88 (0.46–1.67) | 1.45 (1.12–1.87) | 0.60 (0.19–1.93) |
| Rheumatoid arthritis RF+ (M05) | 38/249 | 1.41 (0.84–2.38) | 2.50 (1.42–4.41) | 0.87 (0.38–2.02) | 1.54 (1.09–2.19) | 0.57 (0.08–4.26) |
| Rheumatoid arthritis RF– (M06) | 12/115 | 1.41 (0.68–2.95) | 0.35 (0.05–2.59) | 1.11 (0.34–3.66) | 1.07 (0.59–1.94) | 1.19 (0.15–9.33) |
| Other inflammatory polyarthritis (M13) | 24/164 | 1.72 (1.04–2.85) | 1.79 (1.10–2.91) | 0.55 (0.07–4.13) | 1.56 (1.01–2.43) | 0.43 (0.06–3.11) |
| Sjögren’s syndrome (M35.0) | 12/61 | 2.36 (0.97–5.72) | 1.49 (0.45–4.99) | 2.15 (0.60–7.73) | 2.00 (1.07–3.73) | ** |
| Systemic lupus erythematosus (M32) | 7/42 | 1.85 (0.72–4.77) | ** | 3.69 (0.69–19.85) | 1.71 (0.77–3.80) | ** |
| WG (M31.3) | 4/14 | 2.60 (0.56–12.04) | 2.10 (0.25–17.46) | ** | 2.98 (0.99–8.97) | ** |
| Ankylosing spondylitis (M45) | 10/61 | 2.14 (0.92–4.97) | 1.75 (0.41–7.45) | ** | 1.69 (0.81–3.50) | ** |