Frequencies of HLA-DRB1 alleles in RA patients with or without pulmonary fibrosis.
| HLA-DRB1 | Alleles | With Pulmonary Fibrosis, n = 44 (%) | Without Pulmonary Fibrosis, n = 87 (%) | p | OR (95% CI) | pc |
|---|---|---|---|---|---|---|
| SE+ | *0101 | 4 (4.5) | 10 (5.7) | 0.7789 | 0.78 (0.24–2.56) | 16.3569 |
| *0401 | 5 (5.7) | 9 (5.2) | > 0.9999 | 1.10 (0.36–3.40) | ||
| *0404 | 1 (1.1) | 0 (0) | 0.3359 | 7.0539 | ||
| *0405 | 27 (30.7) | 59 (33.9) | 0.5994 | 0.86 (0.50–1.50) | 12.5874 | |
| *0410 | 2 (2.3) | 4 (2.3) | > 0.9999 | 0.99 (0.18–5.50) | ||
| *1001 | 1 (1.1) | 0 (0) | 0.3359 | 7.0539 | ||
| *1406 | 0 (0) | 4 (2.3) | 0.3039 | 6.3819 | ||
| SE− | *0403 | 0 (0) | 2 (1.1) | 0.5522 | 11.5962 | |
| *0406 | 2 (2.3) | 8 (4.6) | 0.5030 | 0.48 (0.10–2.32) | 10.5630 | |
| *0802 | 2 (2.3) | 1 (0.6) | 0.2618 | 4.02 (0.36–44.9) | 5.4978 | |
| *0803 | 0 (0) | 9 (5.2) | 0.0311 | 0.6531 | ||
| *0809 | 0 (0) | 0 (0) | > 0.9999 | |||
| *0901 | 15 (17.0) | 28 (16.1) | 0.8440 | 1.07 (0.54–2.13) | 17.7240 | |
| *1101 | 1 (1.1) | 5 (2.9) | 0.6670 | 0.39 (0.04–3.38) | 14.0070 | |
| *1201 | 3 (3.4) | 7 (4.0) | > 0.9999 | 0.84 (0.21–3.34) | ||
| *1202 | 2 (2.3) | 2 (1.1) | 0.6042 | 2.00 (0.28–14.4) | 12.6882 | |
| *1301 | 0 (0) | 0 (0) | > 0.9999 | |||
| *1302 | 1 (1.1) | 6 (3.4) | 0.4294 | 0.32 (0.04–2.72) | 9.0174 | |
| *1401 | 1 (1.1) | 1 (0.6) | > 0.9999 | 1.99 (0.12–32.2) | ||
| *1403 | 0 (0) | 1 (0.6) | > 0.9999 | |||
| *1405 | 0 (0) | 0 (0) | > 0.9999 | |||
| *1501 | 2 (2.3) | 5 (2.9) | > 0.9999 | 0.78 (0.15–4.14) | ||
| *1502 | 18 (20.5) | 11 (6.3) | 0.0006 | 3.81 (1.71–8.49) | 0.0126 | |
| *1602 | 1 (1.1) | 2 (1.1) | > 0.9999 | 0.99 (0.09–11.1) | ||
| SE+ total | 40 (45.5) | 86 (49.4) | 0.5435 | 0.85 (0.51–1.43) | ||
| SE− total | 48 (54.5) | 88 (50.6) |
SE: shared epitope.