Frequencies of HLA-DRB1 alleles in RA patients and controls.
| HLA-DRB1 | Alleles | RA, n = 131 (%) | Control, n = 63 (%) | p | OR 9 (5% CI) | pc |
|---|---|---|---|---|---|---|
| SE+ | *0101 | 14 (5.3) | 7 (5.6) | 0.9311 | 0.96 (0.38–2.44) | 22.3464 |
| *0401 | 14 (5.3) | 2 (1.6) | 0.0814 | 3.50 (0.79–15.6) | 1.9536 | |
| *0404 | 1 (0.4) | 0 (0) | > 0.9999 | |||
| *0405 | 86 (32.8) | 18 (14.3) | 0.0001 | 2.93 (1.67–5.14) | 0.0024 | |
| *0410 | 6 (2.3) | 1 (0.8) | 0.4355 | 2.93 (0.35–24.6) | 10.4520 | |
| *1001 | 1 (0.4) | 1 (0.8) | 0.5446 | 0.48 (0.03–7.72) | 13.0704 | |
| *1406 | 4 (1.5) | 4 (3.2) | 0.2811 | 0.47 (0.12–1.92) | 6.7464 | |
| SE− | *0403 | 2 (0.8) | 1 (0.8) | > 0.9999 | 0.96 (0.09–10.7) | |
| *0406 | 10 (3.8) | 7 (5.6) | 0.4333 | 0.67 (0.25–1.82) | 10.3992 | |
| *0802 | 3 (1.1) | 6 (4.8) | 0.0635 | 0.23 (0.06–0.94) | 1.5240 | |
| *0803 | 9 (3.4) | 13 (10.3) | 0.0061 | 0.31 (0.13–0.74) | 0.1464 | |
| *0809 | 0 (0) | 1 (0.8) | 0.3247 | 7.7928 | ||
| *0901 | 43 (16.4) | 16 (12.7) | 0.3401 | 1.35 (0.73–2.50) | 8.1624 | |
| *1101 | 6 (2.3) | 3 (2.4) | > 0.9999 | 0.96 (0.24–3.91) | ||
| *1201 | 10 (3.8) | 0 (0) | 0.0030 | 0.0720 | ||
| *1202 | 4 (1.5) | 2 (1.6) | > 0.9999 | 0.96 (0.17–5.32) | ||
| *1301 | 0 (0) | 2 (1.6) | 0.1049 | 2.5176 | ||
| *1302 | 7 (2.7) | 9 (7.1) | 0.0381 | 0.36 (0.13–0.98) | 0.9144 | |
| *1401 | 2 (0.8) | 6 (4.8) | 0.0162 | 0.15 (0.03–0.77) | 0.3888 | |
| *1403 | 1 (0.4) | 3 (2.4) | 0.1025 | 0.16 (0.02–1.53) | 2.4600 | |
| *1405 | 0 (0) | 4 (3.2) | 0.0108 | 0.2592 | ||
| *1501 | 7 (2.7) | 12 (9.5) | 0.0034 | 0.26 (0.10–0.68) | 0.0816 | |
| *1502 | 29 (11.1) | 8 (6.3) | 0.1383 | 1.84 (0.81–4.14) | 3.3192 | |
| *1602 | 3 (1.1) | 0 (0) | 0.5540 | |||
| SE+ total | 126 (48.1) | 33 (26.2) | < 0.0001 | 2.61 (1.64–4.16) | ||
| SE− total | 136 (51.9) | 93 (73.8) |
SE: shared epitope.