Genotype frequencies of TGF-ß and IL-4 genes in patients with RA.
| Genotype | Without Pulmonary Fibrosis, n = 87 n (%) | With Pulmonary Fibrosis, n = 44 n (%) | OR (95% CI) | p |
|---|---|---|---|---|
| TGF-ß codon 10 | ||||
| T/T | 23 (26.4) | 12 (27.3) | 1.04 (0.46–2.36) | 0.919 |
| T/C | 43 (49.4) | 16 (36.4) | 0.58 (0.28–1.23) | 0.156 |
| C/C | 21 (24.1) | 16 (36.4) | 1.80 (0.82–3.94) | 0.142 |
| IL-4 intron 3 | ||||
| RP1/RP1 | 46 (52.9) | 18 (40.9) | 0.62 (0.30–1.29) | 0.196 |
| RP1/RP2 | 32 (36.8) | 21 (47.7) | 1.57 (0.75–3.27) | 0.228 |
| RP2/RP2 | 9 (10.3) | 5 (11.4) | 1.11 (0.35–3.54) | > 0.999 |
| IL-4 −590 | ||||
| T/T | 43 (49.4) | 18 (40.9) | 0.71 (0.34–1.47) | 0.356 |
| C/T | 37 (42.5) | 21 (47.7) | 1.23 (0.60–2.56) | 0.572 |
| C/C | 7 (8.0) | 5 (11.4) | 1.47 (0.44–4.91) | 0.536 |
TGF: transforming growth factor; IL-4: interleukin 4.