Table 1.

Characteristics of the French and Italian samples, separately and combined. Values are means ± SD, or numbers (%) of observations.

CharacteristicSample
French, n = 467Italian, n = 698p*Combined, n = 1165
Women/men401/66628/700.051029/136
Age, yrs57 ± 1362 ± 14< 0.000160 ± 14
Cutaneous subtype
  Limited297 (63)518 (74)0.0001815 (70)
  Diffuse170 (37)180 (26)0.0001350 (30)
Disease duration, yrs11 ± 914 ± 8< 0.000113 ± 8
History of digital ulcers175 (37)279 (40)0.33454 (39)
Pulmonary fibrosis on computed tomography scan184 (39)217 (31)0.006401 (34)
Renal crisis7 (1.5)10 (1)0.6217 (1)
Antinuclear antibodies > 1/160399 (85)676 (97)< 0.00011075 (92)
Antitopoisomerase I antibodies108 (23)184 (26)0.27292 (24)
Anticentromere I antibodies165 (35)342 (49)< 0.0001507 (43)
Forced vital capacity < 70% predicted80 (17)116 (17)0.94196 (17)
DLCO/AV < 70% predicted159 (34)363 (52)< 0.0001522 (45)
Immunosuppressive therapy55 (12)164 (23)< 0.0001219 (19)
  • * French versus Italian sample. DLCO/AV: carbon monoxide diffusion capacity/alveolar volume.