Subjects’ demographic data by initial treatment.
| Variable | Febuxostat 80 mg, N = 649 | Febuxostat 120 mg, N = 292 | Allopurinol, N = 145 |
|---|---|---|---|
| Serum urate (mg/dl), n (%) | |||
| < 9.0 | 183 (28.2) | 97 (33.2) | 36 (24.8) |
| 9.0 to < 10.0 | 219 (33.7) | 90 (30.8) | 54 (37.2) |
| ≥ 10.0 | 247 (38.1) | 105 (36.0) | 55 (37.9) |
| Mean ± SD | 9.83 ± 1.253 | 9.74 ± 1.281 | 9.82 ± 1.157 |
| Renal function, n (%) | |||
| Normal | 636 (98.0) | 286 (97.9) | 144 (99.3) |
| Impaired* | 13 (2.0) | 6 (2.1) | 1 (0.7) |
| Medical history, n (%) | |||
| Cardiovascular disease | 71 (10.9) | 33 (11.3) | 14 (9.7) |
| Congestive heart failure | 11 (1.7) | 8 (2.7) | 0 |
| Diabetes | 46 (7.1) | 15 (5.1) | 12 (8.3) |
| Hypercholesterolemia | 48 (7.4) | 16 (5.5) | 9 (6.2) |
| Hyperlipidemia | 229 (35.3) | 89 (30.5) | 47 (32.4) |
| Hypertension | 295 (45.5) | 115 (39.4) | 73 (50.3) |
| Alcohol use, n (%) | |||
| Drinker† | 433 (66.74) | 197 (67.5) | 105 (72.4) |
| Non-/Ex-drinker | 216 (33.3) | 95 (32.5) | 40 (27.6) |
| Race, n (%) | |||
| Asian | 19 (2.9) | 4 (1.4) | 5 (3.4) |
| Black or African American | 51 (7.9) | 30 (10.3) | 15 (10.3) |
| White | 519 (80.0) | 233 (79.8) | 110 (75.9) |
| Hispanic or Latino | 40 (6.2) | 15 (5.1) | 11 (7.6) |
| Other | 20 (3.1) | 10 (3.4) | 4 (2.8) |
| Age, yrs, n (%) | |||
| < 45 | 192 (29.6) | 86 (29.5) | 45 (31.0) |
| 45 to 65 | 373 (57.5) | 178 (61.0) | 89 (61.4) |
| > 65 | 84 (12.9) | 28 (9.6) | 11 (7.6) |
| Mean ± SD | 51.4 ± 11.95 | 50.9 ± 11.57 | 51.0 ± 11.30 |
| Range | 24–84 | 24–84 | 29–83 |
| Weight, lb | |||
| Mean ± SD | 223.3 ± 43.01 | 230.3 ± 47.87 | 234.7 ± 49.69 |
| Range | 123–390 | 135–399 | 136–468 |
| BMI, kg/m2, n (%) | |||
| < 18.5 | 0 | 0 | 0 |
| 18.5 to < 25 | 40 (6.2) | 10 (3.4) | 6 (4.1) |
| 25 to < 30 | 215 (33.1) | 92 (31.5) | 42 (29.0) |
| ≥ 30 | 394 (60.7) | 189 (64.7) | 97 (66.9) |
| Missing | 0 | 1 (0.3) | 0 |
| Mean ± SD | 32.3 ± 5.78 | 33.2 ± 6.17 | 33.8 ± 6.79 |
| Range | 21–61 | 22–59 | 21–65 |
| Height, in | |||
| Mean ± SD | 69.7 ± 3.24 | 69.8 ± 3.18 | 69.9 ± 3.32 |
| Range | 59–80 | 61–78 | 59–79 |