Differences in mean baseline SF-36 and HAQ-DI scores by severity of pain and functional status, as evaluated by gout subjects and physicians*.
| Severity Group | BP | GH | MH | PF | RE | RP | SF | VT | MCS | PCS | HAQ-DI |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Gout-related pain | |||||||||||
| Mild | 57.8 | 55.4 | 73.9 | 58.3 | 75.7 | 59.2 | 77.0 | 5.9 | 51.4 | 39.2 | 0.58 |
| Moderate | 42.8 | 49.6 | 75.3 | 42.1 | 57.0 | 22.7 | 65.6 | 49.6 | 51.3 | 30.5 | 1.1 |
| Severe | 22.1 | 35.1 | 58.2 | 29.8 | 27.8 | 4.2 | 38.5 | 37.4 | 41.2 | 25.1 | 1.57 |
| p | < 0.0001 | < 0.002 | 0.003 | 0.0002 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.02 | 0.0008 | < 0.0001 | < 0.0001 |
| Patient-assessed gout-related functioning | |||||||||||
| Mild | 53.8 | 56.0 | 74.0 | 56.6 | 73.3 | 53.6 | 75.0 | 51.8 | 51.3 | 37.6 | 0.67 |
| Moderate | 44.4 | 50.3 | 75.7 | 47.0 | 58.3 | 22.5 | 65.4 | 49.1 | 50.7 | 32.0 | 1.02 |
| Severe | 22.1 | 28.0 | 54.2 | 20.0 | 20.0 | 5.0 | 35.6 | 35.4 | 39.4 | 23.4 | 1.7 |
| p | < 0.0001 | < 0.0001 | 0.0003 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.009 | 0.0002 | < 0.0001 | < 0.0001 |
| Physician-assessed gout-related functioning | |||||||||||
| Mild | 52.1 | 57.2 | 72.2 | 55.9 | 65.4 | 48.2 | 73.9 | 51.9 | 50.1 | 37.7 | 0.66 |
| Moderate | 43.0 | 45.4 | 73.5 | 41.1 | 57.1 | 26.7 | 62.9 | 47.1 | 50.1 | 30.5 | 1.04 |
| Severe | 27.1 | 29.1 | 61.8 | 29.8 | 41.7 | 12.5 | 40.6 | 37.0 | 43.4 | 24.3 | 1.72 |
| p | 0.0003 | < 0.0001 | 0.11 | 0.001 | 0.13 | 0.001 | < 0.0001 | 0.02 | 0.08 | < 0.0001 | < 0.0001 |
↵* Severity categories are based upon responses to 10-cm visual analog scale (VAS) for gout-related pain (0 = no pain, 10 = worst possible pain), patient-assessed gout-related functioning (0 = very well, 10 = very poor), and physician assessed gout-related functioning (0 = very good, 10 = very bad). For each measure, VAS scores were categorized into mild = 0–3.25, moderate = 3.5–6.5, and severe = 6.75–10. BP: bodily pain, GH: general health, MH: mental health, PF: physical functioning, RE: role-emotional functioning, RP: role-physical functioning, SF: social functioning, VT: vitality, MCS: mental component summary score, PCS: physical component summary score.