Table 3.

Annual total post-index resource utilization of study sample, by cohort. Data are mean number (SD), except where indicated.

CharacteristicRA Alone, n = 8,916RA + CVD, n = 608RA + Depression, n = 716RA + CVD + Depression, n = 58
Mean (SD)Mean (SD)p*Mean (SD)p*Mean (SD)p*
Medications
    NSAID2.07 (3.57)1.52 (3.03)< 0.0011.94 (3.37)0.8660.74 (1.60)0.025
    COX-2 inhibitors1.25 (2.98)1.05 (2.57)0.1531.28 (2.83)0.1851.16 (3.08)0.603
    Narcotic analgesics2.65 (5.66)4.60 (11.51)< 0.0016.07 (9.27)< 0.00112.59 (13.60)< 0.001
    Corticosteroids3.31 (4.53)3.87 (4.77)< 0.0013.91 (5.22)< 0.0014.34 (4.61)0.007
    MTX5.10 (5.77)4.70 (5.59)0.0234.79 (5.78)0.1383.31 (4.28)0.006
    Cytotoxic DMARD0.22 (1.47)0.25 (1.46)0.0560.18 (1.13)0.6470.84 (2.57)< 0.001
    Noncytotoxic DMARD1.31 (3.32)1.07 (2.97)0.1861.22 (3.02)0.9081.26 (3.30)0.719
    Etanercept1.77 (4.08)1.55 (3.46)0.5281.43 (3.27)0.2892.36 (4.20)0.214
    Adalimumab0.50 (2.08)0.38 (1.84)0.0770.51 (2.06)0.7870.34 (1.25)0.923
    Infliximab0.98 (4.92)0.95 (2.48)0.2491.06 (4.34)0.4291.12 (2.64)0.232
    Anakinra0.05 (0.65)0.04 (0.49)0.8530.04 (0.42)0.6380.07 (0.41)0.083
  CV-related medications5.43 (10.05)18.57 (17.13)< 0.0016.62 (10.73)< 0.00120.78 (17.29)< 0.001
  Depression-related medications1.45 (3.77)2.37 (5.03)< 0.0018.71 (7.40)< 0.00111.95 (7.67)< 0.001
  Other medications20.69 (19.93)28.32 (28.14)< 0.00133.58 (27.02)< 0.00153.48 (35.15)< 0.001
  Total medication utilization46.79 (34.42)69.24 (49.95)< 0.00171.34 (44.77)< 0.001114.34 (62.30)< 0.001
Outpatient
  Emergency room0.13 (0.44)0.33 (1.15)< 0.0010.35 (0.90)< 0.0010.76 (0.93)< 0.001
  Management16.68 (19.90)23.81 (22.48)< 0.00128.44 (36.46)< 0.00142.02 (34.40)< 0.001
  CABG/angioplasty/PTCA0.00 (0.02)0.02 (0.18)< 0.0010.00 (0.04)0.0220.00 (0.00)0.937
  RA-related surgery0.11 (0.81)0.08 (0.65)0.5660.17 (0.93)0.0250.29 (1.23)0.038
  Inflammation markers2.76 (3.98)2.88 (4.36)0.7343.09 (4.52)0.0322.86 (5.73)0.316
  Tendon injections0.09 (0.46)0.19 (1.12)< 0.0010.18 (0.73)< 0.0010.12 (0.38)0.125
  Arthrocentesis0.54 (1.60)0.83 (2.52)< 0.0010.73 (1.78)< 0.0010.90 (1.96)0.12
  Lab/radiology28.33 (24.55)38.26 (39.65)< 0.00135.41 (28.91)< 0.00146.66 (35.77)< 0.001
  Other outpatient ancillary17.07 (21.56)31.43 (36.48)< 0.00126.19 (40.74)< 0.00137.36 (35.55)< 0.001
Inpatient
  Hospitalizations0.14 (0.54)0.43 (0.91)< 0.0010.32 (0.93)< 0.0010.84 (1.21)< 0.001
  Days in hospital0.85 (5.10)2.92 (11.29)< 0.0012.13 (12.49)< 0.0017.36 (18.13)< 0.001
Evidence of hospitalization, n (%)
  All hospitalizations875 (9.8%)163 (26.8%)< 0.001130 (18.2%)< 0.00126 (44.8%)< 0.001
  RA-related hospitalizations483 (5.4%)57 (9.4%)< 0.00166 (9.2%)< 0.0019 (15.5%)< 0.001
  CV-related hospitalizations0 (0.0)51 (8.4%)< 0.0013 (0.4%)< 0.0017 (12.1%)< 0.001
  Depression-related hospitalizations2 (0.0%)1 (0.2%)0.05617 (2.4%)0.0562 (3.4%)< 0.001
  • * Reference group is RA Alone. CVD: cardiovascular disease, CABG: coronary artery bypass graft, PTCA: percutaneous transluminal coronary angioplasty.