Disease activity (DAS28), erosive status (Sharp-van der Heijde score), and physical disability (HAQ score) by MBL2 genotype and anti-CCP status in patients with early untreated RA stratified by anti-CCP status (positive, n = 93; negative, n = 65). Data are median (range).
| Homozygous-defective 0/0, n = 8 | Intermediate Group, n = 101 | High Producers YA/YA, n = 49 | p* | |
|---|---|---|---|---|
| Disease activity | ||||
| Anti-CCP-positive | 4.6 (3.2–5.7) | 5.5 (2.2–7.9) | 5.7 (2.5–8.4) | 0.02 |
| Anti-CCP-negative | 5.8 (5.5–6.4) | 5.5 (2.4–7.8) | 5.6 (3.8–7.9) | 0.89 |
| Erosive status | ||||
| Anti-CCP-positive | 6 (0–24) | 3 (0–24) | 4 (0–37) | 0.86 |
| Anti-CCP-negative | 3 (0–6) | 1 (0–26) | 2 (0–24) | 0.98 |
| Physical disability | ||||
| Anti-CCP-positive | 0.25 (0.13–0.63) | 1.0 (0–2.9) | 1.1 (0–2.6) | 0.01 |
| Anti-CCP-negative | 1.1 (0.4–1.1) | 0.88 (0–2.4) | 0.50 (0–2.0) | 0.19 |
↵* Jonckheere-Terpstra test for trend.