Characteristics of the French Caucasian cohort of patients with systemic sclerosis.
| Patients, n (%) | SSc cohort for ACE ID (n = 494) | SSc cohort for ACE SNP (n = 659) |
|---|---|---|
| Age, yrs ± SD | 57 ± 14 | 59 ± 11 |
| Sex, female | 416 (84) | 574 (87) |
| Disease duration, yrs ± SD | 12 ± 9 | 11 ± 8 |
| Diffuse cutaneous subtype | 163 (33) | 216 (33) |
| Pulmonary fibrosis | 194 (39) | 271 (41) |
| DLCO/VA < 75% | 160 (32) | 291 (44) |
| Pulmonary arterial hypertension | 34 (7) | 47 (7) |
| Digital ulcerations | 162 (33) | 203 (31) |
| Renal crisis | 3 (1) | 10 (1.5) |
| Positive antitopoisomerase I Abs | 119 (24) | 163 (25) |
| Positive anticentromere Abs | 179 (36) | 270 (41) |
SSc: systemic sclerosis; ACE: angiotensin-converting enzyme; DLCO/VA: diffusing capacity for carbon monoxide divided by alveolar volume; Abs: antibodies; SNP: single nucleotide polymorphism; SD: standard deviation.