Table 4.

Systemic and other risk factors for osteonecrosis of the jaw (ONJ).

* Concomitant malignant disease and chemotherapy1,17,38,66,79

* Glucocorticoid therapy1,17,35,66,80

* Diabetes1,38,81

* Advanced age: in review of cases of ONJ in patients with multiple myeloma, there was a 9% increase in the risk of developing ONJ with each decade of life82

* Smoking and alcohol need to be evaluated further