Characteristics of the membranous nephritis treated with mycophenolate mofetil (MMF, N = 15) and cyclophosphamide (CYC, N = 8) as induction therapy.
| NR, N =4 | MMF R, N = 11 | p | NR, N = 5 | CYC R, N = 3 | p | |
|---|---|---|---|---|---|---|
| Mean age, yrs | 34.5 ± 2.6 | 31.5 ± 1.5 | 0.51 | 38.8 ± 3.5 | 34.7 ± 11.8 | 1.00 |
| Sex, female | 4 | 9 | NS | 5 | 2 | NS |
| Race, no. | ||||||
| Caucasian | 0 | 1 | 1.00 | 1 | 1 | 1.00 |
| African American | 1 | 4 | 1.00 | 0 | 1 | 0.38 |
| Hispanic | 1 | 2 | 1.00 | 1 | 0 | 1.00 |
| Asian | 1 | 2 | 1.00 | 2 | 1 | 1.00 |
| Unknown | 1 | 2 | — | 1 | 0 | |
| Serum creatinine, mg/dl | 1.1 ± 0.4 | 0.95 ± 0.1 | 0.79 | 1.6 ± 0.6 | 0.87 ± 0.12 | 0.79 |
| Serum albumin, g/dl | 3.3 ± 0.05 | 2.8 ± 0.3 | 0.12 | 3.0 ± 0.2 | 2.5 ± 0.03 | 0.07 |
| Abnormal complement, no. | 3 | 5 | 0.57 | 3 | 3 | 0.46 |
| Presence of anti-dsDNA, no. | 2 | 4 | 1.00 | 3 | 3 | 0.46 |
| Proteinuria, g/24 h | 2.6 ± 0.38 | 4.3 ± 0.80 | 0.77 | 3.9 ± 0.9 | 6.7 ± 1.8 | 0.25 |
| Abnormal sediment, no. | 2 | 6 | NS | 2 | 2 | NS |
| Duration of lupus nephritis, yrs | 7.8 ± 2.7 | 4.9 ± 1.9 | 0.42 | 3.5 ± 1.2 | 2.3 ± 1.9 | 0.47 |
| Prior CYC treatment, no. | 3/4 | 0/8 | 1/4 | 1/3 | ||
| Prior MMF treatment, no. | 2/4 | 1/8 | 3/4 | 0/3 | ||
NR: nonresponder; R: responder; NS: nonsignificant; NA: nonapplicable.
† Statistically different; p value < 0.05. ± Standard error of mean.