Comparison of live birth rates for women with recurrent pregnancy loss and aPL. Results from 8 randomized clinical trials from 1996 to 2008 evaluating either unfractionated heparin or low molecular weight heparin in combination with aspirin.
| Author, year | n | Determination of aPL Positivity | Intervention | Live Births (%) |
|---|---|---|---|---|
| Kutteh, 1996 13 | 25 | aCL IgG ≥ 27 or IgM ≥ 27 (Pos LAC excluded) | ASA 81 mg/day + sc UFH 5000 U bid | 20/25 (80.0) |
| Rai, 1997 14 | 45 | aCL IgG > 5 or IgM > 3 or LAC (RVVT) | ASA 75 mg/day + sc UFH 5000 U bid | 32/45 (71.1) |
| Cowchock, 1992 39 | 26 | aCL IgG > 30 or IgM > 11 or LAC (DRVVT or APPT) | ASA 80 mg/day + sc UFH 10,000 U bid | 19/26 (73.1) |
| Noble, 2005 40 | 25 | aCL IgG > 20 or IgM > 20 or aPS > 3 MOM or LAC (DRVVT) | ASA 80 mg/day + sc UFH 5000 U bid | 20/25 (80.0) |
| Franklin, 2002 41 | 25 | aCL IgG > 20 or IgM > 20 and/or aPS > 3 MOM and/or LAC (DRVVT) | ASA 81 mg/day + sc LMWH 5000 IU bid | 19/25 (76.0) |
| Farquarson, 2002 17 | 51 | aCL IgG > 9 and/or IgM > 5 or LAC (DRVVT) | ASA 75 mg/day + sc LMWH 5000 IU/day | 40/51 (78.4) |
| Noble, 2005 40 | 25 | aCL IgG > 20 and/or IgM > 20 and/or aPS > 3 MOM and/or LAC (DRVVT) | ASA 81 mg/day + sc LMWH 40 mg/day | 21/25 (84.0) |
| Laskin, 2008 | 22 | aCL IgG > 15 and/or IgM > 25 and/or LAC (DRVVT, PTTLA, DilPT, KCT) | ASA 81 mg/day + sc LMWH 5000 IU/day | 17/22 (77.3) |
RPL: recurrent pregnancy loss; UFH: unfractionated heparin; LMWH: low molecular weight heparin; ASA: aspirin; aPL: antiphospholipid antibody; aCL: anticardiolipin; LAC: lupus anticoagulant; DRVVT: dilute Russell’s viper venom time; MOM: multiples of the mean; PTTLA: lupus anticoagulant sensitive partial thromboplastin time; DilPT: dilute prothrombin time.