Clinical features of 6 male patients based on the American College of Rheumatology revised criteria for SLE6. Hematologic abnormalities defined as leukopenia (white blood cells < 4,000 cells/mm3), lymphopenia (lymphocytes < 1,500 cells/mm3), anemia (hemoglobin < 14 g/dl), and/or thrombocytopenia (platelet count < 400,000 cells/mm3) more than once and not explained by other diseases or drug use.
| Patient | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | |
| Current age, yrs | 25 | 42 | 38 | 45 | 37 | 31 |
| Age at diagnosis, yrs | 21 | 30 | 26 | 41 | 34 | 23 |
| Ethnicity | H | AA | H | AA | AA | H |
| Malar rash | – | – | + | – | – | – |
| Photosensitivity | – | + | – | – | + | + |
| Discoid lupus | – | – | – | + | + | – |
| Oral ulcers | + | + | + | – | + | + |
| Serositis | + | + | + | – | + | + |
| Arthritis | + | + | + | – | + | + |
| Renal involvement | + | + | + | – | + | + |
| CNS involvement | + | – | + | – | – | – |
| Hematologic abnormalities | ||||||
| Leukopenia | – | + | – | + | + | – |
| Lymphopenia | + | + | + | + | + | + |
| Anemia | + | + | – | + | + | + |
| Thrombocytopenia | – | + | – | + | + | + |
| Antibodies | ||||||
| Anti-Smith | – | – | – | + | – | – |
| Anti-RNP | – | – | – | + | + | + |
| Anti-Ro/La | −/− | +/− | −/− | −/− | −/− | −/− |
| Anti-dsDNA | + | + | + | – | + | – |
| Anticardiolipin | + | – | + | – | – | – |
| LAC | – | – | + | – | – | – |
| ANA | + | + | + | + | + | + |
H: Hispanic, AA: African American; CNS: central nervous system; LAC: lupus anticoagulant; ANA: antinuclear antibodies.