Table 1.

Characteristics of studies. Values are N (%). Numbers are rounded to the nearest digit; total may add up to > 100, since many trials had > 1 type of intervention.

All, n = 1961997, n = 72006, n = 129
Body part
  Upper extremity
    Shoulder3 (2)03 (2)
    Elbow1 (0.5)1 (0.5)0
    Hand3 (2)1 (0.5)2 (1)
  Lower extremity
    Hip100 (51)43 (22)57 (29)
    Knee99 (51)32 (16)67 (34)
    Foot1 (0.5)01 (0.5)
    Long bones3 (2)03 (2)
No. of centers
  Single center70 (36)27 (40)43 (33)
  Multicenter37 (19)15 (22)22 (17)
  Unclear89 (45)25 (37)63 (49)
No. of patients
  ≤ 5069 (35)25 (13)44 (22)
  51–10066 (34)18 (9)48 (25)
  201–50016 (8)7 (4)9 (5)
  > 50014 (7)5 (3)9 (5)
Type of study
  Original183 (94)64 (96)119 (92)
  Followup/subgroup13 (6)3 (2)10 (5)
Type of intervention
  Pharmacological79 (40)32 (48)47 (36)
    Oral medications22 (11)7 (10)15 (8)
    Intramuscular/subcutaneous/nerve block3 (1)03 (2)
    Intravenous22 (11)9 (5)13 (7)
    Intraarticular40 (20)20 (10)20 (10)
  Nonpharmacological130 (66)37 (19)93 (47)
    Surgery80 (40)14 (7)66 (34)
    Arthroscopy/joint lavage2 (1)02 (1)
    Rehabilitation/physiotherapy17 (9)5 (3)12 (6)
    Behavioral intervention3 (2)03 (2)
    Education3 (2)03 (2)
    Other*30 (15)18 (9)12 (6)
Funding support
  No information provided100 (50)46 (69)54 (42)
  None21 (11)3 (5)18 (14)
  Private62 (31)18 (27)44 (34)
  Private and public4 (2)04 (3)
  Public9 (5)09 (7)
Type of journal
  Orthopedics/surgery125 (64)38 (57)87 (67)
  Other/rehabilitation10 (6)14 (20)20 (16)
  Anesthesia34 (17)13 (19)14 (11)
  Internal medicine27 (14)2 (3)9 (6)
  • * Includes diet, ultrasound, electrical stimulation, drainage, irradiation, navigation system, implants, wound dressings, etc.