The genotype and allele frequencies of polymorphisms in the promoter region of CRP gene.
| SLE, n = 148 (%) | NC, n = 137 (%) | p | ||
|---|---|---|---|---|
| −861 T>C | TT | 105 (70.9) | 108 (78.8) | cod: NS |
| CT | 41 (27.7) | 29 (21.2) | dom: NS | |
| CC | 2 (1.4) | 0 (0.0) | rec: NS | |
| q. | 0.152 | 0.106 | al: NS | |
| −821 A>G | AA | 122 (82.4) | 101 (73.7) | cod: NS |
| AG | 23 (15.5) | 32 (23.4) | dom: NS | |
| GG | 3 (2.0) | 4 (2.9) | rec: 0.079 | |
| q. | 0.098 | 0.146 | al: NS | |
| −390 | CC | 78 (52.7) | 96 (70.1) | cod: 0.051 |
| C>A or T | AC | 41 (27.7) | 26 (19.0) | dom: NS |
| CT | 27 (18.2) | 12 (8.8) | rec: 0.033 | |
| AA | 1 (0.7) | 0 (0.0) | ||
| AT | 0 (0.0) | 3 (2.2) | ||
| TT | 1 (0.7) | 0 (0.0) | ||
| q. | 0.243 | 0.161 | al: 0.071 |
Each p value was calculated with codominant (cod), dominant (dom), and recessive models (rec). al: p value of each allele frequency. Logistic regression analysis was applied to control for age and gender as covariables. SLE: systemic lupus erythematosus; NC: normal control; NS: not significant.