Table 3.

Functional findings in patients with TRAPS-like syndrome. Data are percentages.

GroupApoptosis*, median % (range)Shedding** median % (range)
Healthy controls (n = 12)+366 (+87/ +718)−78 (−69/ −89)
TRAPS patients (n = 8)0 (−25/ +50)−48.6 (−31/ −53)
  125−49.2
  2ND−36.1
  331−50.3
  4ND−42.3
  546.7ND

  • ↵* Expressed as percentage change of annexin V-positive cells after stimulation with tumor necrosis factor and cycloheximide compared to untreated cells;

  • ↵** expressed as percentage change of p55 TNFR1 expression after PMA stimulation (see D’Osualdo, et al15). ND: not determined.