Table 2.

Significant variables for relapse in univariate Cox regression analysis.

Variable	Relapse, N = 16	No Relapse, N = 28	HR	95% CI	p
MMF dose reduction (%)^†
Group 2	6 (23)	20 (77)	1.00	—	—
Group 1	10 (56)	8 (44)	3.37	(1.18–9.69)	0.024
MMF dose, median (range), g/day^*^†
Per 0.5-g increase	1.8 (1.3–2)	2 (1.2–3)	0.56	(0.36–0.88)	0.011
Type of initial reduction of MMF dose (%)
No reduction	6 (23)	20 (77)	1.00	—	—
1.5 g/day or 75% of initial dose	3 (43)	4 (57)	3.21	(1.10–10.76)	0.031
1 g/day or 50% of initial dose	7 (64)	4 (36)	3.44	(1.11–9.26)	0.033
Time from remission to dose reduction (%)
No reduction	6 (23)	20 (77)	1.00	—	—
≤ 18 mo	7 (88)	1 (130	6.85	(2.21–21.22)	0.001
> 18 mo	3 (30)	7 (70)	1.14	(0.35–3.73)	0.822
Time from complete remission to dose reduction (%)^*, N = 32
No reduction	5 (25)	15 (75)	1.00	—	—
≤ 18 mo	6 (86)	1 (14)	6.29	(1.52–26.07)	0.011
> 18 mo	1 (20)	4 (80)	0.78	(0.13–4.80)	0.788

↵* Weighted average dose each patient received taking into consideration the time spent on each drug dosage during the whole followup.
↵† Time-dependent analysis. MMF: mycophenolate mofetil; HR: hazard ratio.