PT  - JOURNAL ARTICLE
AU  - Kiyoshi Migita
AU  - Tadashi Nakamura
AU  - Yumi Maeda
AU  - Taichiro Miyashita
AU  - Tomoki Origuchi
AU  - Hiroshi Yatsuhashi
AU  - Minoru Nakamura
AU  - Hiromi Ishibashi
AU  - Katsumi Eguchi
TI  - HLA-DRB1*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis.
DP  - 2006 Nov 01
TA  - The Journal of Rheumatology
PG  - 2120--2123
VI  - 33
IP  - 11
4099  - http://www.jrheum.org/content/33/11/2120.short
4100  - http://www.jrheum.org/content/33/11/2120.full
SO  - J Rheumatol2006 Nov 01; 33
AB  - OBJECTIVE: To compare the HLA-DRB1 shared epitope (SE) alleles in Japanese patients with rheumatoid arthritis (RA) and amyloid A (AA) amyloidosis versus those without AA amyloidosis. METHODS: The HLA-DRB1 alleles were genotyped for 91 RA patients without AA amyloidosis, 33 RA patients with AA amyloidosis, and 63 control subjects. HLA-DRB1 typing was performed by polymerase chain reaction, sequence-specific oligonucleotide probe hybridization method. RESULTS: Although a significant difference was not observed, the frequency of SE genotype was higher in RA patients with AA amyloidosis than in those without AA amyloidosis. All SE-positive RA patients with AA amyloidosis had *04 alleles (*0401, *0405, *0410), and a significant association of the presence of a double dose of *04 SE alleles with AA amyloidosis (OR 4.0, 95% CI 1.91-13.99) was observed. CONCLUSION: Our data suggest that presence of double *04 SE is associated with a higher risk of developing AA amyloidosis in Japanese patients with RA.