RT Journal Article
SR Electronic
T1 Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2088
OP 2090
VO 33
IS 10
A1 Evelyne Vinet
A1 Eric Rich
A1 Jean-Luc Senécal
YR 2006
UL http://www.jrheum.org/content/33/10/2088.abstract
AB Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare disorder characterized by a bleeding tendency due to factor II deficiency associated with the presence of lupus anticoagulant (LAC) autoantibodies. We describe a patient with systemic lupus erythematosus and LAHPS in whom successful treatment of central nervous system bleeding due to severe factor II deficiency was followed by a major thromboembolic complication. Literature review revealed 2 other patients with LAHPS who developed thrombosis resulting from the treatment of factor II deficiency. We suggest that factor II deficiency counterbalances the prothrombotic effect of LAC in LAHPS, and correcting this deficiency may promote thromboembolism.