TY - JOUR T1 - Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease. JF - The Journal of Rheumatology JO - J Rheumatol SP - 2085 LP - 2087 VL - 33 IS - 10 AU - Samy K Metyas AU - Hal M Hoffman Y1 - 2006/10/01 UR - http://www.jrheum.org/content/33/10/2085.abstract N2 - OBJECTIVE: Familial cold autoinflammatory syndrome (FCAS) is a rare, hereditary disorder characterized by cold-induced inflammation. We describe the successful longterm treatment of a patient with FCAS with anakinra, an interleukin 1 receptor antagonist (IL-1Ra). The remarkable response of FCAS and associated Raynaud's disease in this patient suggests that IL-1 is an important mediator of these inflammatory diseases. Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases. ER -