RT Journal Article
SR Electronic
T1 Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1843
OP 1845
VO 32
IS 9
A1 Shyam Prabhakaran
A1 Matthew Bramlage
A1 Mark A Edgar
A1 Betty Diamond
A1 John A Hardin
A1 Bruce T Volpe
YR 2005
UL http://www.jrheum.org/content/32/9/1843.abstract
AB We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.