PT  - JOURNAL ARTICLE
AU  - Shyam Prabhakaran
AU  - Matthew Bramlage
AU  - Mark A Edgar
AU  - Betty Diamond
AU  - John A Hardin
AU  - Bruce T Volpe
TI  - Overwhelming leukoencephalopathy as the only sign of neuropsychiatric lupus.
DP  - 2005 Sep 01
TA  - The Journal of Rheumatology
PG  - 1843--1845
VI  - 32
IP  - 9
4099  - http://www.jrheum.org/content/32/9/1843.short
4100  - http://www.jrheum.org/content/32/9/1843.full
SO  - J Rheumatol2005 Sep 01; 32
AB  - We describe a patient with diffuse leukoencephalopathy, a rare central nervous system complication of systemic lupus erythematosus, who died of brain herniation despite aggressive management. Brain magnetic resonance imaging revealed diffuse white matter hyperintensities consistent with vasogenic edema. Autopsy revealed only widespread cerebral edema. Early recognition and persistent, aggressive treatment will be required to avoid this fatal and rare manifestation of neuropsychiatric lupus.