TY - JOUR T1 - Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee. JF - The Journal of Rheumatology JO - J Rheumatol SP - 1615 LP - 1618 VL - 32 IS - 8 AU - Nobuo Adachi AU - Mitsuo Ochi AU - Masataka Deie AU - Yohei Ito Y1 - 2005/08/01 UR - http://www.jrheum.org/content/32/8/1615.abstract N2 - We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA). We confirmed successful cartilage-like tissue regeneration by a second arthroscopy. Biopsy of the repaired tissue revealed cartilage-like regeneration and bone formation. We were able to regenerate new bone and cartilage-like tissue in a one-stage operation, without sacrificing autologous bone or other tissue. This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis. ER -