TY - JOUR T1 - Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105. JF - The Journal of Rheumatology JO - J Rheumatol SP - 562 LP - 564 VL - 32 IS - 3 AU - Syuichi Koarada AU - Masaru Ide AU - Yoshio Haruta AU - Yoshifumi Tada AU - Osamu Ushiyama AU - Fumitaka Morito AU - Akihide Ohta AU - Kohei Nagasawa Y1 - 2005/03/01 UR - http://www.jrheum.org/content/32/3/562.abstract N2 - B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE. ER -