RT Journal Article
SR Electronic
T1 Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 562
OP 564
VO 32
IS 3
A1 Syuichi Koarada
A1 Masaru Ide
A1 Yoshio Haruta
A1 Yoshifumi Tada
A1 Osamu Ushiyama
A1 Fumitaka Morito
A1 Akihide Ohta
A1 Kohei Nagasawa
YR 2005
UL http://www.jrheum.org/content/32/3/562.abstract
AB B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.