PT  - JOURNAL ARTICLE
AU  - Syuichi Koarada
AU  - Masaru Ide
AU  - Yoshio Haruta
AU  - Yoshifumi Tada
AU  - Osamu Ushiyama
AU  - Fumitaka Morito
AU  - Akihide Ohta
AU  - Kohei Nagasawa
TI  - Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
DP  - 2005 Mar 01
TA  - The Journal of Rheumatology
PG  - 562--564
VI  - 32
IP  - 3
4099  - http://www.jrheum.org/content/32/3/562.short
4100  - http://www.jrheum.org/content/32/3/562.full
SO  - J Rheumatol2005 Mar 01; 32
AB  - B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.