TY - JOUR T1 - Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy. JF - The Journal of Rheumatology JO - J Rheumatol SP - 1349 LP - 1351 VL - 31 IS - 7 AU - Takehiko Mori AU - Hideto Kameda AU - Hiroe Ogawa AU - Atsushi Iizuka AU - Naoya Sekiguchi AU - Hirofumi Takei AU - Hayato Nagasawa AU - Michihide Tokuhira AU - Toshio Tanaka AU - Yumiko Saito AU - Koichi Amano AU - Toru Abe AU - Tsutomu Takeuchi Y1 - 2004/07/01 UR - http://www.jrheum.org/content/31/7/1349.abstract N2 - OBJECTIVE: To evaluate the incidence and effect of cytomegalovirus (CMV) reactivation in patients with inflammatory connective tissue diseases (CTD) undergoing immunosuppressive therapy. METHODS: A total of 18 consecutive CMV seropositive patients undergoing immunosuppressive therapy for inflammatory CTD were enrolled. CMV reactivation was determined by detection of CMV-DNA in peripheral blood leukocytes (PBL) or plasma using quantitative real-time polymerase chain reaction. RESULTS: CMV reactivation was detected in PBL in 7 of 17 evaluable patients (41%), and in plasma in 5 of 17 patients (29%). Patients with detectable CMV-DNA in plasma were exclusively positive for CMV-DNA in PBL. Conclusion. Patients with inflammatory CTD under immunosuppressive therapy are at high risk for CMV reactivation. The clinical significance of such an event and indications for antiviral therapy should be examined further. ER -