@article {Zeng1451, author = {Xiaofeng Zeng and Maixing Ai and Xinping Tian and Xiaodan Gan and Yanping Shi and Qinfang Song and Fulin Tang}, title = {Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis.}, volume = {30}, number = {7}, pages = {1451--1455}, year = {2003}, publisher = {The Journal of Rheumatology}, abstract = {OBJECTIVE: To explore the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) detected by ELISA in patients with rheumatoid arthritis (RA). METHODS: The synthesized cyclic citrullinated peptide was used as substrate for ELISA. Anti-CCP antibody was detected by ELISA in 191 patients with RA, 132 with rheumatic diseases other than RA, and 98 with nonrheumatic diseases. The antiperinuclear factor (APF), anti-keratin antibody (AKA), rheumatoid factor (RF), and HLA-DR4 gene complex were also tested in each RA patient. The results of these tests were compared with anti-CCP antibody to examine the correlation between them. RESULTS: Ninety (47.1\%) patients with RA, 4 (3.0\%) with other rheumatic diseases, and 2 (2.0\%) with nonrheumatic diseases were found to be anti-CCP antibody positive by ELISA. The sensitivity of anti-CCP antibody was 47.1\%, with a high specificity (97.4\%) in RA. Anti-CCP antibody correlated with APF, AKA, RF, and HLA-DR4 gene complex. CONCLUSION: A new modified anti-CCP antibody test had a moderate sensitivity (47.1\%) but a high specificity (97.4\%) in patients with RA and was found as a valuable supplement to diagnosis of RA. Anti-CCP correlated with APF, AKA, RF, and HLA-DR4 gene complex, but did not completely overlap with them. Anti-CCP antibody could be regarded as a new diagnostic marker for RA.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/30/7/1451}, eprint = {https://www.jrheum.org/content/30/7/1451.full.pdf}, journal = {The Journal of Rheumatology} }