PT  - JOURNAL ARTICLE
AU  - Dinesh Khanna
AU  - Michael R Liebling
AU  - James S Louie
TI  - Etanercept ameliorates sarcoidosis arthritis and skin disease.
DP  - 2003 Aug 01
TA  - The Journal of Rheumatology
PG  - 1864--1867
VI  - 30
IP  - 8
4099  - http://www.jrheum.org/content/30/8/1864.short
4100  - http://www.jrheum.org/content/30/8/1864.full
SO  - J Rheumatol2003 Aug 01; 30
AB  - Sarcoidosis is a systemic disorder of unknown etiology characterized by its pathological hallmark, the noncaseating granuloma. In granulomatous diseases, the proinflammatory peptide mediators, including tumor necrosis factor-alpha (TNF-alpha), are increased in the blood and fluids surrounding the activated macrophages. We describe a patient with chronic sarcoidosis arthropathy and lupus pernio resistant to corticosteroids and disease modifying antirheumatic agents, who responded to the addition of etanercept. We discuss the possible mechanisms of action of anti-TNF agents in granulomatous diseases and suggest that chronic, resistant sarcoidosis requires combination immunosuppressive therapy.