RT Journal Article SR Electronic T1 Salazosulfapyridine-induced remission of Felty's syndrome along with significant reduction in neutrophil-bound immunoglobulin G. JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 404 OP 406 VO 30 IS 2 A1 Keiko Ishikawa A1 Yoshito Tsukada A1 Shigeo Tamura A1 Yoriaki Kaneko A1 Takashi Kuroiwa A1 Kazue Ueki A1 Tomoko Sugiura A1 Yoshihisa Nojima YR 2003 UL http://www.jrheum.org/content/30/2/404.abstract AB Felty's syndrome is characterized by neutropenia, splenomegaly, and leg ulcers in patients with rheumatoid arthritis. The pathogenesis of the neutropenia is an immune-mediated process that involves immune complexes, antineutrophil antibodies, and abnormal white cell kinetics. We prescribed salazosulfapyridine to a 65-year-old woman with this syndrome. The neutropenia improved along with a reduction in neutrophil-bound IgG, demonstrated by flow cytometric analysis. Salazosulfapyridine may be of benefit for the treatment of Felty's syndrome, and flow cytometry can be used to monitor disease activity and therapeutic efficacy.