RT Journal Article
SR Electronic
T1 No association of vitamin D receptor gene start codon fok 1 polymorphisms in Chinese patients with systemic lupus erythematosus.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1211
OP 1213
VO 29
IS 6
A1 Chung-Ming Huang
A1 Mei-Chen Wu
A1 Jer-Yuarn Wu
A1 Fuu-Jen Tsai
YR 2002
UL http://www.jrheum.org/content/29/6/1211.abstract
AB OBJECTIVE: To examine whether the start codon Fok I of the vitamin D receptor (VDR) gene polymorphism is a marker of susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients in Taiwan. METHODS: A control group of 90 healthy people and 52 patients with SLE were examined. Using polymerase chain reaction (PCR) based restriction analysis, we evaluated the relationship between Fok I polymorphisms and SLE, where an unexcisable length was determined to be 265 bp (FF), and the 2 fragments measuring 169 bp and 96 bp were determined to be excisable lengths (ff). RESULTS: For the genotype of VDR Fok I start codon polymorphism, there were no statistically significant differences between the 2 groups (chi-squared test, p = 0.07). Additionally, we did not detect any association of VDR genotype with the clinical and laboratory profiles in SLE patients. CONCLUSION: Our results suggest that the vitamin D receptor Fok I start codon polymorphism is not related to patients with SLE in Taiwan.