RT Journal Article
SR Electronic
T1 Intercellular adhesion molecule-1 gene polymorphisms in isolated polymyalgia rheumatica.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 502
OP 504
VO 29
IS 3
A1 Mahsa M Amoli
A1 Emma Shelley
A1 Derek L Mattey
A1 Carlos Garcia-Porrua
A1 Wendy Thomson
A1 Ali H Hajeer
A1 William E R Ollier
A1 Miguel A Gonzalez-Gay
YR 2002
UL http://www.jrheum.org/content/29/3/502.abstract
AB OBJECTIVE: In untreated polymyalgia rheumatica (PMR), high levels of circulating soluble intercellular adhesion molecule-1 (ICAM-1) have been observed. To investigate the clinical implication of ICAM-1 polymorphisms in isolated PMR, we examined their potential influence in an unselected series of patients. METHODS: We studied 72 patients with isolated PMR and 129 ethnically matched controls from Lugo, Spain. Patients and controls were genotyped for HLA-DRB1 and ICAM-1 polymorphism at codons 241 and 469 by molecular methods. RESULTS: The distribution of alleles and genotypes for each ICAM-1 polymorphism did not show significant differences between patients with isolated PMR and controls. There were also no associations between ICAM-1 polymorphisms and relapses of the disease. The latter was primarily associated with carriage of an HLA-DRB1*0401 allele (OR 7.2, p = 0.01), although all relapsed patients with HLA-DRB1*0401 also carried the GG genotype of the ICAM-1 polymorphism at codon 241. The presence of both HLA-DRB1*0401 and the GG241 ICAM-1 genotype gave an OR of 15.2 (p = 0.005) after correction for age and sex. CONCLUSION: Although ICAM-1 polymorphisms alone do not appear to be associated with disease severity in isolated PMR, the presence of both HLA-DRB1*0401 and the ICAM-1 codon 241 GG homozygosity was significantly associated with increased risk of relapses in these patients.