RT Journal Article
SR Electronic
T1 Cytokines and depression in cases with fibromyalgia.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 358
OP 361
VO 29
IS 2
A1 Ali Gür
A1 Mehmet Karakoç
A1 Kemal Nas
A1 Remzi
A1 Cevik
A1 Aziz Denli
A1 Jale Saraç
YR 2002
UL http://www.jrheum.org/content/29/2/358.abstract
AB OBJECTIVE: Fibromyalgia (FM) is a chronic, painful musculoskeletal disorder characterized by widespread pain, pressure, hyperalgesia, morning stiffness, and an increased incidence of depressive symptoms. The etiology, however, has remained elusive. The aim of the present study was to examine the inflammatory response system in FM and to investigate the effect of depression level on serum cytokines. METHODS: Serum interleukin-1 (IL-I), IL-2 receptor (IL-2r), IL-6, and IL-8 and the Hamilton Depression Rating Scale (HDRS) score were determined in 32 healthy volunteers and in 81 patients with FM, classified according to the American College of Rheumatology criteria. RESULTS: In our study, serum IL-1 and IL-6 were not statistically significant, but serum IL-8, IL2r, and HDRS score were significantly higher in patients with FM than the control group (p < 0.01). In addition, in patients with FM, IL-8 was found to be related to pain intensity (r = 0.35; p < 0.01). CONCLUSION: IL-8 may play an important role in the occurrence of pain in FM.