PT  - JOURNAL ARTICLE
AU  - A Ravelli
AU  - M C Caria
AU  - S Buratti
AU  - C Malattia
AU  - F Temporini
AU  - A Martini
TI  - Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
DP  - 2001 Apr 01
TA  - The Journal of Rheumatology
PG  - 865--867
VI  - 28
IP  - 4
4099  - http://www.jrheum.org/content/28/4/865.short
4100  - http://www.jrheum.org/content/28/4/865.full
SO  - J Rheumatol2001 Apr 01; 28
AB  - Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.