TY - JOUR T1 - Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis. JF - The Journal of Rheumatology JO - J Rheumatol SP - 865 LP - 867 VL - 28 IS - 4 AU - A Ravelli AU - M C Caria AU - S Buratti AU - C Malattia AU - F Temporini AU - A Martini Y1 - 2001/04/01 UR - http://www.jrheum.org/content/28/4/865.abstract N2 - Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA. ER -