RT Journal Article
SR Electronic
T1 Juvenile rheumatoid arthritis-like polyarthritis in Nijmegen breakage syndrome.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2548
OP 2550
VO 28
IS 11
A1 S D Rosenzweig
A1 R A Russo
A1 M Gallego
A1 M Zelazko
YR 2001
UL http://www.jrheum.org/content/28/11/2548.abstract
AB Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disease (8q21) from the family of the genetically determined chromosomal instability syndromes. The disorder is characterized by microcephaly, growth retardation, immunodeficiency, and high incidence of cancer. Several noninflammatory anomalies of the musculoskeletal system have been described in patients with this syndrome. We describe an Argentinian girl with all the clinical, immunological, and cytogenic characteristics described for NBS plus a juvenile rheumatoid arthritis-like syndrome. To our knowledge this is the first report of a patient with the NBS who presented with a symmetric chronic polyarthritis resembling JRA.