TY - JOUR T1 - Juvenile rheumatoid arthritis-like polyarthritis in Nijmegen breakage syndrome. JF - The Journal of Rheumatology JO - J Rheumatol SP - 2548 LP - 2550 VL - 28 IS - 11 AU - S D Rosenzweig AU - R A Russo AU - M Gallego AU - M Zelazko Y1 - 2001/11/01 UR - http://www.jrheum.org/content/28/11/2548.abstract N2 - Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disease (8q21) from the family of the genetically determined chromosomal instability syndromes. The disorder is characterized by microcephaly, growth retardation, immunodeficiency, and high incidence of cancer. Several noninflammatory anomalies of the musculoskeletal system have been described in patients with this syndrome. We describe an Argentinian girl with all the clinical, immunological, and cytogenic characteristics described for NBS plus a juvenile rheumatoid arthritis-like syndrome. To our knowledge this is the first report of a patient with the NBS who presented with a symmetric chronic polyarthritis resembling JRA. ER -