@article {Fautrel322, author = {B Fautrel and G Le Mo{\"e}l and B Saint-Marcoux and P Taupin and S Vignes and S Rozenberg and A C Koeger and O Meyer and L Guillevin and J C Piette and P Bourgeois}, title = {Diagnostic value of ferritin and glycosylated ferritin in adult onset Still{\textquoteright}s disease.}, volume = {28}, number = {2}, pages = {322--329}, year = {2001}, publisher = {The Journal of Rheumatology}, abstract = {OBJECTIVE: To determine the usefulness of serum ferritin and glycosylated ferritin (GF) levels in diagnosing adult onset Still{\textquoteright}s disease (AOSD). METHODS: We performed a retrospective multicenter study of 205 patients who had ferritin and GF assays in one hospital laboratory. Records of all patients were reviewed, and a standardized questionnaire used to extract all data available at the time of the assay. The clinicians{\textquoteright} final diagnosis was also recorded. Patients were classified as having "certain AOSD" (based on Yamaguchi{\textquoteright}s criteria) or a control disease. The concordance of ferritin and GF levels with final diagnosis was evaluated. RESULTS: In total 49 AOSD and 120 control patients were eligible. The mean ferritin value was significantly higher in the AOSD group (4,752 +/- 9,599 microg/l) than in the control group (1,571 +/- 3,807 microg/l), p = 0.029. GF was significantly lower in AOSD patients (15.9 +/- 11.9\%) than in the control group (31.5 +/- 18.7\%), p \< 0.001. The combination of a GF level of \< or = 20\% with ferritin above the upper limit of normal yielded a sensitivity of 70.5\% and specificity of 83.2\%. The combination of a GF level \< or = 20\% with ferritin 5 times normal produced a sensitivity of 43.2\% and specificity of 92.9\%. This latter combination allowed an AOSD diagnosis to be ruled out for 6 of the 8 control patients who met Yamaguchi{\textquoteright}s positive criteria. CONCLUSION: Ferritin and GF levels are powerful diagnostic markers of AOSD. They may be helpful in clinical practice for excluding differential diagnoses.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/28/2/322}, eprint = {https://www.jrheum.org/content/28/2/322.full.pdf}, journal = {The Journal of Rheumatology} }