TY - JOUR T1 - Removal of hyaline articular cartilage reduces lymphocyte infiltration and activation in rheumatoid synovial membrane. JF - The Journal of Rheumatology JO - J Rheumatol SP - 2184 LP - 2189 VL - 28 IS - 10 AU - Y T Konttinen AU - T F Li AU - J Lassus AU - V Waris AU - S Santavirta AU - I Virtanen Y1 - 2001/10/01 UR - http://www.jrheum.org/content/28/10/2184.abstract N2 - OBJECTIVE: To analyze the effect of removal of hyaline articular cartilage on synovial membrane pathology in chronic arthritis. METHODS: Synovial membrane samples were obtained from patients with rheumatoid arthritis or ankylosing spondylitis in association with total hip arthroplasty, either primary or revision surgery. Synovial membrane histopathology was assessed by immunochemical staining and morphometry. RESULTS: CD68 positive macrophages were common in revision synovial membranes. In contrast, T lymphocytes were much more common in primary rheumatoid synovial membranes (p < 0.001). Many T lymphocytes in primary synovial membrane were HLA-D/DR positive (p < 0.001) and interleukin 2 receptor (IL-2R) positive (p < 0.001) and contained interferon-gamma(IFN-gamma; p < 0.001) and tumor necrosis factor-beta (TNF-beta; p < 0.001). In contrast, revision synovial membranes from patients with chronic arthritis contained only a few HLA-D/DR positive T cells and practically no IL-2R, IFN-gamma, or TNF-beta positive activated T lymphocytes. CONCLUSION: The components of hyaline articular cartilage may be the source of autoantigen responsible for perpetuation of chronic arthritides. ER -