RT Journal Article
SR Electronic
T1 High Prevalence of Subclinical Left Ventricular Dysfunction in Patients with Psoriatic Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1363
OP 1370
DO 10.3899/jrheum.101136
VO 38
IS 7
A1 QING SHANG
A1 LAI-SHAN TAM
A1 GABRIEL WAI-KWOK YIP
A1 JOHN E. SANDERSON
A1 QING ZHANG
A1 EDMUND KWOK-MING LI
A1 CHEUK-MAN YU
YR 2011
UL http://www.jrheum.org/content/38/7/1363.abstract
AB Objective. Endothelial dysfunction and early atherosclerosis have been found in patients with psoriatic arthritis (PsA) without cardiovascular disease (CVD) risk factors. Few studies have investigated whether there is any early impairment of myocardial function. The aims of our study were to determine the prevalence of subclinical left ventricular (LV) dysfunction in PsA patients and the disease-related risk factors. Methods. Ninety-four PsA patients without clinical evidence of CVD and 63 healthy subjects were enrolled. All underwent conventional echocardiography and tissue Doppler imaging. Results. Sixty-one (65%) patients with PsA had evidence of subclinical LV dysfunction as defined by mean myocardial peak systolic velocity (Sm) of basal 6 segments < 4.4 cm/s, lateral E’ < 11.5 cm/s, and/or lateral E/E’ > 10. Thirty-six (38%) patients had only diastolic dysfunction, 4 (4%) had only systolic dysfunction, and 21 (22%) had both systolic and diastolic dysfunction. PsA patients with subclinical LV dysfunction were older, had a higher age at diagnosis of PsA and of psoriasis, a longer disease duration, a higher prevalence of hypertension and hyperlipidemia, higher levels of serum creatinine, and more antihypertensive treatment than those with normal LV function. Multivariate regression showed that age at diagnosis of PsA > 40 years (OR 3.388, 95% CI 1.065–10.777, p = 0.039) and hypertension (OR 4.732, 95% CI 1.345–16.639, p = 0.015) were independent predictors of subclinical LV dysfunction. Conclusion. PsA patients without established CVD disease and in the absence of traditional CV risk factors have a high prevalence of subclinical LV dysfunction.