RT Journal Article SR Electronic T1 Dr. Balevic, et al, reply JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.200681 DO 10.3899/jrheum.200681 A1 Stephen J. Balevic A1 Christoph P. Hornik A1 Thomas P. Green A1 Megan E.B. Clowse A1 Daniel Gonzalez A1 Anil R. Maharaj A1 Laura E. Schanberg A1 Amanda M. Eudy A1 Geeta K. Swamy A1 Brenna L. Hughes A1 Michael Cohen-Wolkowiez YR 2020 UL http://www.jrheum.org/content/early/2020/05/20/jrheum.200681.abstract AB We read with great interest the very thoughtful commentary by Drs. Joob and Wiwanitkit. We agree with the authors that, despite conflicting clinical data to date, it is possible that HCQ may have a protective effect in the setting of COVID-19. More importantly, we agree that optimal HCQ dosage and timing is a critical underpinning for clinical trials. However, we highlight several considerations regarding treatment with high dose HCQ.