RT Journal Article
SR Electronic
T1 Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 924
OP 927
DO 10.3899/jrheum.181205
VO 47
IS 6
A1 Anna Postolova
A1 Megan L. Troxell
A1 Irene L. Wapnir
A1 Mark C. Genovese
YR 2020
UL http://www.jrheum.org/content/47/6/924.abstract
AB Objective. Idiopathic granulomatous mastitis (IGM) is a disfiguring inflammatory breast disease without effective treatment. We report the largest IGM cohort treated with methotrexate (MTX) monotherapy.Methods. Chart review was performed on patients evaluated by the Stanford Immunology and Rheumatology Clinic, with histopathologically established IGM treated with MTX, and at least 1 followup appointment.Results. Nineteen female patients with a mean age of 33.5 years were identified. Most failed treatment with antibiotics, prednisone, and surgical intervention. By 15 months of treatment with MTX, 94% had disease improvement and 75% achieved disease remission.Conclusion. MTX monotherapy is an effective treatment for IGM.