RT Journal Article
SR Electronic
T1 Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health Related Quality of Life in Sjögren’s syndrome?
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP jrheum.190849
DO 10.3899/jrheum.190849
A1 Yasemin Şahinkaya
A1 Gonca Mumcu
A1 Filiz Türe  Özdemir
A1 Ramazan Esad  Kuruş
A1 Ali Uğur  Ünal
A1 Haner Direskeneli
A1 George A.  Bruyn
A1 Nevsun Inanc
YR 2020
UL http://www.jrheum.org/content/early/2020/04/27/jrheum.190849.abstract
AB Objective Ultrasonography of major salivary glands (SGUS) is a widely used imaging technique to evaluate salivary gland involvement in primary Sjögren’s syndrome (pSS). The aim of this study was to evaluate the relationship between SGUS, salivary flow rate (SFR) as an objective measure of the gland function and oral health-related quality of life (OHRQoL) as a patientreported outcome measure (PROM) in a pSS cohort. Methods Sixty-six patients with pSS were examined by SGUS according to Hocevar and Milic scoring systems. Patients with inhomogeneity/hypoechoic areas with scores ≥2 in parotid and submandibular glands were classified separately as severe glandular involvement. Furthermore, oral health, SFR and oral health impact profile-14 (OHIP-14) for OHRQoL were assessed. Results Both total Hocevar and Milic scores were higher in 21 pSS patients with low unstimulated whole salivary flow rate (U-WSFR) than 45 pSS patients without low U-WSFR (p=0.001 and p<0.0001, respectively). Increased scores of homogeneity, hypoechoic areas and glandular border visibility were observed in patients with low U-WSFR (p<0.05). Among these variables, homogeneity score was found to be an independent risk factor for low UWSFR in pSS according to logistic regression analysis (OR:1.586, p=0.001). Moreover, a higher OHIP-14 score was observed in severe parotid involvement compared to non-severe ones (23.26 ± 21.19 vs 8.32 ±13.82, p=0.004). Conclusion High Milic and Hocevar SGUS scores are associated with reduced SFRs and poor OHRQoL as a PROM. US inhomogeneity of salivary glands is associated with low UWSFR and is a good indicator of severely affected gland function.