RT Journal Article SR Electronic T1 Relationship Between Fatigue and Inflammation, Disease Duration, and Chronic Pain in Psoriatic Arthritis: An Observational DANBIO Registry Study JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 548 OP 552 DO 10.3899/jrheum.181412 VO 47 IS 4 A1 Marie Skougaard A1 Tanja Schjødt Jørgensen A1 Signe Rifbjerg-Madsen A1 Laura C. Coates A1 Alexander Egeberg A1 Kirstine Amris A1 Lene Dreyer A1 Pil Højgaard A1 Jørgen Guldberg-Møller A1 Joseph F. Merola A1 Peder Frederiksen A1 Henrik Gudbergsen A1 Lars Erik Kristensen YR 2020 UL http://www.jrheum.org/content/47/4/548.abstract AB Objective. Fatigue is one of the most significant symptoms, and an outcome of great importance, in patients with psoriatic arthritis (PsA), but associations between underlying components of fatigue experienced by patients in relation to the disease have been sparsely investigated. The objectives were to describe the degree of fatigue in patients with PsA, and to examine important components associated with fatigue.Methods. We performed a cross-sectional survey including patients registered in the Danish nationwide registry DANBIO from December 2013 to June 2014. Principal component analysis (PCA) was used to identify factors associated with fatigue.Results. A total of 1062 patients with PsA were included in the study. A PCA reduced co-variables into 3 components explaining 63% of fatigue in patients. The first component, contributing to 31% of fatigue, was composed of inflammatory factors including swollen and tender joints, physician’s global assessment, elevated C-reactive protein (CRP), and high Pain Detect Questionnaire (PDQ) score. The second component, contributing to 17% of fatigue, consisted of increasing age and long disease duration. The third component, contributing to 15% of fatigue, consisted of high PDQ score, tender joint count, increasing age, and concomitant low CRP, suggestive of a chronic pain component consisting of central pain sensitization or structural joint damage.Conclusion. Fatigue in patients with PsA may be driven by clinical inflammatory factors, disease duration, and chronic pain in the absence of inflammation.