TY - JOUR T1 - Juvenile Dermatomyositis and Development of Malignancy: 2 Case Reports and a Literature Review JF - The Journal of Rheumatology JO - J Rheumatol SP - 479 LP - 479 DO - 10.3899/jrheum.190929 VL - 47 IS - 3 AU - LAURA CANNON AU - JEFFREY DVERGSTEN AU - CORY STINGL Y1 - 2020/03/01 UR - http://www.jrheum.org/content/47/3/479.abstract N2 - To the Editor:In adults, there is an established correlation between dermatomyositis (DM) and malignancy1, but in children there are very few case reports in the literature. Here we report 2 cases from our institution of development of leukemia after diagnosis of juvenile DM (JDM).Written consent was provided from the patients (and their parents) included in this report. The Duke University Health System institutional review board (IRB) does not require IRB approval for case reports describing 2 patients.Case 1An obese 6-year-old white girl was admitted with weakness and rash over the preceding 6 months with associated weight loss, fever, and joint pain. Family history was negative for malignancy, immunodeficiency, and autoimmunity. On examination, she had symmetric proximal muscle weakness, heliotrope rash, Gottron papules, nailbed telangiectasias, and no evidence of organomegaly. She had an initial Childhood Myositis Assessment Scale (CMAS) of 14/52. Additionally, she had elevated muscle enzymes, muscle edema on magnetic resonance imaging (MRI), as well as electromyography consistent with myositis. She had a positive antinuclear antibody (ANA), negative … Address correspondence to Dr. L. Cannon, Division of Pediatric Rheumatology, Department of Pediatrics, Duke Children’s Hospital, 2301 Erwin Road, Durham, North Carolina 27710, USA. E-mail: laura.cannon{at}duke.edu ER -