TY - JOUR T1 - Prevalence and Risk Factors for Major Infections in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis: Influence on the Disease Outcome JF - The Journal of Rheumatology JO - J Rheumatol SP - 407 LP - 414 DO - 10.3899/jrheum.190065 VL - 47 IS - 3 AU - Eloi Garcia-Vives AU - Alfons Segarra-Medrano AU - Ferran Martinez-Valle AU - Irene Agraz AU - Roser Solans-Laque Y1 - 2020/03/01 UR - http://www.jrheum.org/content/47/3/407.abstract N2 - Objective. To analyze the role that infections play on the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) outcome.Methods. A retrospective study of adult patients with AAV diagnosed in a tertiary center. Clinical features, laboratory findings, treatment, relapses, major infections, and outcome were evaluated.Results. Included were 132 patients [51 microscopic polyangiitis (MPA), 52 granulomatosis with polyangiitis (GPA), 29 eosinophilic GPA (EGPA)] with a mean followup of 140 (96–228) months. ANCA were positive in 85% of cases. A total of 300 major infections, mainly bacterial (85%), occurred in 60% patients during the followup. Lower respiratory tract (64%) and urinary tract infections (11%) were the most frequent, followed by bacteremia (10%). A total of 7.3% opportunistic infections were observed, most due to systemic mycosis. Up to 46% of all opportunistic infections took place in the first year of diagnosis, and 55% of them under cyclophosphamide (CYC) treatment. Bacterial infections were associated with Birmingham Vasculitis Activity Score (version 3) > 15 at the disease onset, a total cumulative CYC dose > 8.65 g, dialysis, and development of leukopenia during the followup. Leukopenia was the only factor independently related to opportunistic infections. Forty-four patients died, half from infection. Patients who had major infections had an increased mortality from any cause.Conclusion. Our results confirm that major infections are the main cause of death in patients with AAV. ER -