TY - JOUR T1 - Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis? JF - The Journal of Rheumatology JO - J Rheumatol DO - 10.3899/jrheum.191082 SP - jrheum.191082 AU - Sergey Moiseev AU - Anastasiia Zykova AU - Nikolay Bulanov AU - Evgeny Gitel AU - Pavel Novikov AU - Mayra Bulanova AU - Andreas Kronbichler AU - David Jayne Y1 - 2020/02/15 UR - http://www.jrheum.org/content/early/2020/02/10/jrheum.191082.abstract N2 - Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAV) form a group of necrotizing small-vessel vasculitides characterized by the presence of ANCA against either proteinase 3 (PR3) or myeloperoxidase (MPO). ANCA have a key role in the pathogenesis of AAV, inducing excessive activation of neutrophils, which results in injury to small vessels1. ANCA can target other neutrophil-derived molecules, among them lysosome-associated membrane glycoprotein 2 (LAMP-2). ER -