@article {Moiseevjrheum.191082, author = {Sergey Moiseev and Anastasiia Zykova and Nikolay Bulanov and Evgeny Gitel and Pavel Novikov and Mayra Bulanova and Andreas Kronbichler and David Jayne}, title = {Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody{\textendash}associated Vasculitis?}, elocation-id = {jrheum.191082}, year = {2020}, doi = {10.3899/jrheum.191082}, publisher = {The Journal of Rheumatology}, abstract = {Antineutrophil cytoplasmic antibody (ANCA){\textendash}associated vasculitides (AAV) form a group of necrotizing small-vessel vasculitides characterized by the presence of ANCA against either proteinase 3 (PR3) or myeloperoxidase (MPO). ANCA have a key role in the pathogenesis of AAV, inducing excessive activation of neutrophils, which results in injury to small vessels1. ANCA can target other neutrophil-derived molecules, among them lysosome-associated membrane glycoprotein 2 (LAMP-2).}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/early/2020/02/10/jrheum.191082}, eprint = {https://www.jrheum.org/content/early/2020/02/10/jrheum.191082.full.pdf}, journal = {The Journal of Rheumatology} }