RT Journal Article SR Electronic T1 Neurophysiological features of peripheral nervous system involvement and immunological profile of patients with primary Sjögren syndrome JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP jrheum.181464 DO 10.3899/jrheum.181464 A1 Joanna Perzyńska-Mazan A1 Maria Maślińska A1 Robert Gasik YR 2020 UL http://www.jrheum.org/content/early/2020/02/10/jrheum.181464.abstract AB Objective The aim of this study was to evaluate: the prevalence, type of neuropathy and the relationship between the presence of autoantibodies and neuropathy development in patients with primary Sjögren syndrome (pSS). Methods 61 pSS patients underwent a complete neurological and electrophysiological examination as well as immunological tests including rheumatoid factor (RF) and autoantibodies as antinuclear antibodies, (ANA), anti-Ro/SSa, anti-La/SSB antibodies. Results The axonal loss or demyelination were found in 39 patients (63.9%). 29 (47.5%) subjects fulfilled both clinical and electrophysiological criteria of peripheral neuropathy of predominantly axonal type. Seropositivity to both anti-Ro and anti-La antibodies was more frequently found in patients with normal nerve conduction study. Seropositivity to anti-Ro alone was present in the majority of patients with axonal neuropathy (p<0.05). The presence of RF was associated with several electrodiagnostic signs of demyelination (p<0.01). The ANA titer showed no independent association with neuropathy. Conclusion Peripheral neuropathy is a frequent complication in patients with primary Sjögren syndrome. Seropositivity limited to anti-Ro is associated with increased risk of axonal neuropathy in comparison to seropositivity to both anti-Ro and anti-La antibodies. Seropositivity to RF may contribute to demyelination.